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Insider

Best NFL DFS matchups for Week 6

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Berry discusses Abdullah's performance vs. Panthers (0:39)

Matthew Berry breaks down Ameer Abdullah and the struggling Lions offense. (0:39)

If you had the foresight to stack Brian Hoyer with tight end George Kittle in Week 5, then hats off to you. We sometimes forget that DFS roster construction isn't really about using good players, but banking on players who can be great for just that game. That's why it never hurts to throw a few darts at the bargain bin.

Perhaps the biggest issue in Week 6 is figuring out if any Steelers are going to shine in Kansas City, and if the Chiefs will continue to roll as the No. 1 offense in that game. Beyond that, we have some division games between the Packers-Vikings and Patriots-Jets that could suppress fantasy scoring. You also might want to lower your fantasy expectations for Lions-Saints (a non-competitive dud last year) and Eagles-Panthers (Thursday night) this week.

Here are the best and worst fantasy matchups for Week 6:

(Note: References to defensive rankings are based on Football Outsiders' DVOA metric, explained here).

Quarterbacks

Mid-tier lock of the week: Deshaun Watson vs. Cleveland

Watson is the first quarterback in NFL history to have two games with at least four touchdown passes in his first four starts. While you might think he'll cool off this week, the matchup is still too good with a Cleveland defense that has been rotten against the pass. The Browns are allowing quarterbacks to complete 74.0 percent of their passes with 11 touchdowns and three interceptions. Stack Watson with DeAndre Hopkins and look for the rookie to continue his prolific run.