Bellator MMA officials broke the news with The New York Post on Monday. The fight will co-headline Bellator's pay-per-view event from inside Madison Square Garden, along with a grudge match featuring Chael Sonnen and Wanderlei Silva.
The fight, which will mark Emelianenko's Bellator debut, was originally supposed to headline Bellator 172 last month. The promotion was forced to cancel the bout just hours before the event, however, when Mitrione was hospitalized with kidney stones.
Emelianenko (36-4) is considered by many to be the greatest heavyweight of all time. Now 40, he is currently riding a five-fight win streak, which dates back to 2011. He was retired between 2012 and 2015.
Mitrione (11-5) will be making his third appearance in Bellator. The former UFC heavyweight is 2-0 since swapping promotions last year, with two knockout victories. He has a former career in the NFL, including time spent with the New York Giants.
Bellator 180 will mark just the second PPV event in company history and first since current president Scott Coker joined the promotion in 2014. It will also be the company's first-ever event held in New York.